AEVIOM

AEVIOM

AEVIOM

AEVIOM SCIENCE

Explore the Science
of Longevity

An editorial library dedicated to the major biological mechanisms studied in human and animal aging.

AEVIOM SCIENCE

Explore the Science
of Longevity

An editorial library dedicated to the major biological mechanisms studied in human and animal aging.

NAD+ : Why Your Cellular Energy Collapses After 40
Longevity Science
9 min·Nature · Cell · PubMed
NAD+ : Why Your Cellular Energy Collapses After 40
Its decline after 40 is one of the most extensively documented mechanisms in geroscience.
READ ARTICLE→
The Epigenetic Clock: Can Science Really Measure Your Biological Age?
Longevity Science
8 min·Genome Biology · eLife · Nature Aging · Cell · PubMed
The Epigenetic Clock: Can Science Really Measure Your Biological Age?
Your passport shows your date of birth. But your cells keep a different record. Since Steve Horvath’s work in 2013, science has developed tools to measure real biological age — independently of chronological age.
READ ARTICLE→
Hallmarks of Aging: The Scientific Framework That Unified Aging Biology
Longevity Science
10 min·Cell 2023 · Cell 2013 · Nature · PubMed
Hallmarks of Aging: The Scientific Framework That Unified Aging Biology
In 2013, López-Otín et al. published in Cell the first unified scientific framework of aging. Ten years later, the 2023 update expanded the mechanisms to twelve.
LIRE L’ARTICLE→
Mitochondrial Dysfunction and Aging: Why Your Cellular Energy Production Declines After 40
Longevity Science
9 min·Nature Reviews MCB · Cell Metabolism · Nature Aging · PubMed
Mitochondrial Dysfunction and Aging: Why Your Cellular Energy Production Declines After 40
Mitochondrial dysfunction is one of the central mechanisms of aging. Understanding why your mitochondria become less efficient after 40 is key to understanding fatigue and progressive energy decline.
READ ARTICLE→
Why Women Live Longer: The Cellular Biology of Sex-Specific Aging
Longevity Science
10 min·Nature Medicine · Cell Metabolism · Nature Aging · Science · PubMed
Why Women Live Longer: The Cellular Biology of Sex-Specific Aging
In nearly every country in the world, women outlive men. This gap is not merely behavioral — geroscience has identified profound biological differences that explain why men and women age differently at the cellular level.
READ ARTICLE→
NAD+ and Coenzyme Q10: Why These Two Molecules Are Complementary in Mitochondrial Biology
Longevity Science
8 min·Cell Metabolism · Nature Reviews MCB · Journal of Clinical Investigation · EPFL · PubMed
NAD+ and Coenzyme Q10: Why These Two Molecules Are Complementary in Mitochondrial Biology
NAD+ and Coenzyme Q10 operate at consecutive stages of the mitochondrial respiratory chain. Their parallel decline with age partly explains the cellular energy collapse commonly observed after 40.
READ ARTICLE→
Circadian Clock and Aging: Why Your Biological Rhythm Shapes Longevity
Longevity Science
7 min·Science · Cell Metabolism · Nature Reviews Neuroscience · Nobel Prize 2017 · PubMed
Circadian Clock and Aging: Why Your Biological Rhythm Shapes Longevity
In 2017, the Nobel Prize in Physiology was awarded for the discovery of the molecular mechanisms governing the circadian clock. Its progressive disruption with age affects sleep, metabolism, immunity, and longevity — through a direct connection with NAD+ and sirtuins.
READ ARTICLE→
Zombie Cells: How Cellular Senescence and Inflammaging Accelerate Aging
Longevity Science
8 min·Nature Medicine · Annual Review of Physiology · Cell · PubMed
Zombie Cells: How Cellular Senescence and Inflammaging Accelerate Aging
Within your body are cells that have stopped functioning but refuse to die. As they accumulate with age, these zombie cells release a pro-inflammatory cocktail that progressively damages surrounding tissues.
READ ARTICLE→
Microbiome intestinal et longévité : ce que les centenaires ont en commun
Science de la longévité
7 min·Nature · Nature Metabolism · Current Biology · Cell Host & Microbe · PubMed
Microbiome intestinal et longévité : ce que les centenaires ont en commun
Le microbiome intestinal est un organe invisible de 1 à 2 kilogrammes dont la composition conditionne l'inflammation chronique, l'immunité et la longévité biologique. Les études sur les centenaires révèlent des signatures microbiomiques distinctives.
LIRE L’ARTICLE→
What the World's Longest-Lived Animals Teach Us About the Biology of Longevity
Longevity Science
10 min·Cell Reports · Nature · Science · PNAS · Nature Communications · PubMed
What the World's Longest-Lived Animals Teach Us About the Biology of Longevity
A whale that has been swimming since before the French Revolution. A rodent that almost never develops cancer. A microscopic organism that survives the vacuum of space. Nature has already engineered biological longevity solutions that geroscience is only now beginning to decode.
READ ARTICLE→
The Longevity Hotel: When Luxury Becomes a Biological Intervention
Longevity Science
10 min·Cell Reports Medicine · NEJM · Cell · Global Wellness Institute
The Longevity Hotel: When Luxury Becomes a Biological Intervention
A new category of establishment has emerged — neither luxury hotel, nor medical clinic, nor wellness spa. Biological age is measured on arrival, protocols are built around biomarkers, and the market is now worth $639 billion. What geroscience actually says about the efficacy of these interventions.
READ ARTICLE→
Exercise and Cellular Aging: What Biology Actually Shows
Longevity Science
9 min·Nature · Cell Metabolism · NEJM · Nature Aging · PubMed
Exercise and Cellular Aging: What Biology Actually Shows
Exercise is the most thoroughly documented longevity intervention in modern medicine. Contemporary cellular biology has mapped the precise molecular mechanisms through which physical activity influences the Hallmarks of Aging — from NAD+ to telomeres, from mitochondria to the epigenome.
READ ARTICLE→
5 Habits That Accelerate Biological Aging
Longevity Science
8 min·Nature Aging · Cell Metabolism · The Lancet Healthy Longevity · NEJM · PubMed
5 Habits That Accelerate Biological Aging
Biological aging is not solely determined by genetics. Certain daily habits directly activate the molecular mechanisms of cellular aging — chronic inflammation, oxidative stress, mitochondrial dysfunction, and accelerated senescence.
READ ARTICLE→
Gut Microbiome and Longevity: What Centenarians Have in Common
Longevity Science
7 min·Nature · Nature Metabolism · Current Biology · Cell Host & Microbe · PubMed
Gut Microbiome and Longevity: What Centenarians Have in Common
The gut microbiome is an invisible 1 to 2-kilogram organ whose composition influences chronic inflammation, immune resilience, and biological longevity. Studies on centenarians reveal distinctive microbiome signatures.
READ ARTICLE→
Blue Zones: What the World’s Longest-Lived Populations Teach Us About the Biology of Aging
Longevity Science
11 min·PNAS · National Geographic · Experimental Gerontology · Nature · Cell · PubMed
Blue Zones: What the World’s Longest-Lived Populations Teach Us About the Biology of Aging
In 2000, a Belgian demographer marked in blue the Sardinian villages with an unmatched concentration of centenarians. The term Blue Zone was born. Today, five regions around the world are recognized as natural laboratories of human longevity.
READ ARTICLE→
NAD+ : Why Your Cellular Energy Collapses After 40
Longevity Science
9 min·Nature · Cell · PubMed
NAD+ : Why Your Cellular Energy Collapses After 40
Its decline after 40 is one of the most extensively documented mechanisms in geroscience.
READ ARTICLE→
Exercise and Cellular Aging: What Biology Actually Shows
Longevity Science
9 min·Nature · Cell Metabolism · NEJM · Nature Aging · PubMed
Exercise and Cellular Aging: What Biology Actually Shows
Exercise is the most thoroughly documented longevity intervention in modern medicine. Contemporary cellular biology has mapped the precise molecular mechanisms through which physical activity influences the Hallmarks of Aging — from NAD+ to telomeres, from mitochondria to the epigenome.
READ ARTICLE→
The Longevity Hotel: When Luxury Becomes a Biological Intervention
Longevity Science
10 min·Cell Reports Medicine · NEJM · Cell · Global Wellness Institute
The Longevity Hotel: When Luxury Becomes a Biological Intervention
A new category of establishment has emerged — neither luxury hotel, nor medical clinic, nor wellness spa. Biological age is measured on arrival, protocols are built around biomarkers, and the market is now worth $639 billion. What geroscience actually says about the efficacy of these interventions.
READ ARTICLE→
NAD+ and Coenzyme Q10: Why These Two Molecules Are Complementary in Mitochondrial Biology
Longevity Science
8 min·Cell Metabolism · Nature Reviews MCB · Journal of Clinical Investigation · EPFL · PubMed
NAD+ and Coenzyme Q10: Why These Two Molecules Are Complementary in Mitochondrial Biology
NAD+ and Coenzyme Q10 operate at consecutive stages of the mitochondrial respiratory chain. Their parallel decline with age partly explains the cellular energy collapse commonly observed after 40.
READ ARTICLE→
Why Women Live Longer: The Cellular Biology of Sex-Specific Aging
Longevity Science
10 min·Nature Medicine · Cell Metabolism · Nature Aging · Science · PubMed
Why Women Live Longer: The Cellular Biology of Sex-Specific Aging
In nearly every country in the world, women outlive men. This gap is not merely behavioral — geroscience has identified profound biological differences that explain why men and women age differently at the cellular level.
READ ARTICLE→
Zombie Cells: How Cellular Senescence and Inflammaging Accelerate Aging
Longevity Science
8 min·Nature Medicine · Annual Review of Physiology · Cell · PubMed
Zombie Cells: How Cellular Senescence and Inflammaging Accelerate Aging
Within your body are cells that have stopped functioning but refuse to die. As they accumulate with age, these zombie cells release a pro-inflammatory cocktail that progressively damages surrounding tissues.
READ ARTICLE→
Hallmarks of Aging: The Scientific Framework That Unified Aging Biology
Longevity Science
10 min·Cell 2023 · Cell 2013 · Nature · PubMed
Hallmarks of Aging: The Scientific Framework That Unified Aging Biology
In 2013, López-Otín et al. published in Cell the first unified scientific framework of aging. Ten years later, the 2023 update expanded the mechanisms to twelve.
READ ARTICLE→
What the World's Longest-Lived Animals Teach Us About the Biology of Longevity
Longevity Science
10 min·Cell Reports · Nature · Science · PNAS · Nature Communications · PubMed
What the World's Longest-Lived Animals Teach Us About the Biology of Longevity
A whale that has been swimming since before the French Revolution. A rodent that almost never develops cancer. A microscopic organism that survives the vacuum of space. Nature has already engineered biological longevity solutions that geroscience is only now beginning to decode.
READ ARTICLE→
5 Habits That Accelerate Biological Aging
Longevity Science
8 min·Nature Aging · Cell Metabolism · The Lancet Healthy Longevity · NEJM · PubMed
5 Habits That Accelerate Biological Aging
Biological aging is not solely determined by genetics. Certain daily habits directly activate the molecular mechanisms of cellular aging — chronic inflammation, oxidative stress, mitochondrial dysfunction, and accelerated senescence.
READ ARTICLE→
Mitochondrial Dysfunction and Aging: Why Your Cellular Energy Production Declines After 40
Longevity Science
9 min·Nature Reviews MCB · Cell Metabolism · Nature Aging · PubMed
Mitochondrial Dysfunction and Aging: Why Your Cellular Energy Production Declines After 40
Mitochondrial dysfunction is one of the central mechanisms of aging. Understanding why your mitochondria become less efficient after 40 is key to understanding fatigue and progressive energy decline.
READ ARTICLE→
The Epigenetic Clock: Can Science Really Measure Your Biological Age?
Longevity Science
8 min·Genome Biology · eLife · Nature Aging · Cell · PubMed
The Epigenetic Clock: Can Science Really Measure Your Biological Age?
Your passport shows your date of birth. But your cells keep a different record. Since Steve Horvath’s work in 2013, science has developed tools to measure real biological age — independently of chronological age.
READ ARTICLE→
Circadian Clock and Aging: Why Your Biological Rhythm Shapes Longevity
Longevity Science
7 min·Science · Cell Metabolism · Nature Reviews Neuroscience · Nobel Prize 2017 · PubMed
Circadian Clock and Aging: Why Your Biological Rhythm Shapes Longevity
In 2017, the Nobel Prize in Physiology was awarded for the discovery of the molecular mechanisms governing the circadian clock. Its progressive disruption with age affects sleep, metabolism, immunity, and longevity — through a direct connection with NAD+ and sirtuins.
READ ARTICLE→
Gut Microbiome and Longevity: What Centenarians Have in Common
Longevity Science
7 min·Nature · Nature Metabolism · Current Biology · Cell Host & Microbe · PubMed
Gut Microbiome and Longevity: What Centenarians Have in Common
The gut microbiome is an invisible 1 to 2-kilogram organ whose composition influences chronic inflammation, immune resilience, and biological longevity. Studies on centenarians reveal distinctive microbiome signatures.
READ ARTICLE→
Blue Zones: What the World’s Longest-Lived Populations Teach Us About the Biology of Aging
Longevity Science
11 min·PNAS · National Geographic · Experimental Gerontology · Nature · Cell · PubMed
Blue Zones: What the World’s Longest-Lived Populations Teach Us About the Biology of Aging
In 2000, a Belgian demographer marked in blue the Sardinian villages with an unmatched concentration of centenarians. The term Blue Zone was born. Today, five regions around the world are recognized as natural laboratories of human longevity.
READ ARTICLE→